ParkinsonV1, Main, Exploration, bibRecord, 000792

CSF Aβ42 and tau in Parkinson's disease with cognitive impairment

Identifieur interne : 000792 ( Main/Exploration ); précédent : 000791; suivant : 000793

CSF Aβ42 and tau in Parkinson's disease with cognitive impairment

Auteurs : Thomas J. Montine [États-Unis] ; Min Shi [États-Unis] ; Joseph F. Quinn [États-Unis] ; Elaine R. Peskind [États-Unis] ; Suzanne Craft [États-Unis] ; Carmen Ginghina [États-Unis] ; Kathryn A. Chung [États-Unis] ; Hojoong Kim [États-Unis] ; Douglas R. Galasko [États-Unis] ; Joseph Jankovic [États-Unis] ; Cyrus P. Zabetian [États-Unis] ; James B. Leverenz [États-Unis] ; Jing Zhang [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-11-15.

RBID : ISTEX:E22F3584401FA8AF62FC70D3542C9D9107AC3FA8

English descriptors

KwdEn :
- Aβ42, CSF biomarkers, Parkinson's disease, cognitive impairment, tau.

Abstract

We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's disease and Dementia (PD‐D) or with PD and Cognitive Impairment, Not Dementia (PD‐CIND). We quantified CSF Aβ42, total tau (T‐tau), and phospho‐tau (P181‐tau) using commercially available kits. Samples were from 345 individuals in seven groups (n): Controls ≤50 years (35), Controls >50 years (115), amnestic Mild Cognitive Impairment (aMCI) (24), AD (49), PD (49), PD‐CIND (62), and PD‐D (11). We observed expected changes in AD or aMCI compared with age‐matched or younger controls. CSF Aβ42 was reduced in PD‐CIND (P < 0.05) and PD‐D (P < 0.01), whereas average CSF T‐tau and P181‐tau were unchanged or decreased. One‐third of PD‐CIND and one‐half of PD‐D patients had the biomarker signature of AD. Abnormal metabolism of Aβ42 may be a common feature of PD‐CIND and PD‐D. © 2010 Movement Disorder Society

Url:

https://api.istex.fr/document/E22F3584401FA8AF62FC70D3542C9D9107AC3FA8/fulltext/pdf

DOI: 10.1002/mds.23287

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 002A15
to stream Main, to step Curation: 002660

Le document en format XML

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<author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name>
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<author><name sortKey="Shi, Min" sort="Shi, Min" uniqKey="Shi M" first="Min" last="Shi">Min Shi</name>
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<author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
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<author><name sortKey="Peskind, Elaine R" sort="Peskind, Elaine R" uniqKey="Peskind E" first="Elaine R." last="Peskind">Elaine R. Peskind</name>
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<front><div type="abstract" xml:lang="en">We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's disease and Dementia (PD‐D) or with PD and Cognitive Impairment, Not Dementia (PD‐CIND). We quantified CSF Aβ42, total tau (T‐tau), and phospho‐tau (P181‐tau) using commercially available kits. Samples were from 345 individuals in seven groups (n): Controls ≤50 years (35), Controls >50 years (115), amnestic Mild Cognitive Impairment (aMCI) (24), AD (49), PD (49), PD‐CIND (62), and PD‐D (11). We observed expected changes in AD or aMCI compared with age‐matched or younger controls. CSF Aβ42 was reduced in PD‐CIND (P < 0.05) and PD‐D (P < 0.01), whereas average CSF T‐tau and P181‐tau were unchanged or decreased. One‐third of PD‐CIND and one‐half of PD‐D patients had the biomarker signature of AD. Abnormal metabolism of Aβ42 may be a common feature of PD‐CIND and PD‐D. © 2010 Movement Disorder Society</div>
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<name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
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<name sortKey="Kim, Hojoong" sort="Kim, Hojoong" uniqKey="Kim H" first="Hojoong" last="Kim">Hojoong Kim</name>
<name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
<name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B." last="Leverenz">James B. Leverenz</name>
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<name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
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<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
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<name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name>
</country>
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</record>

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	Serveur d'exploration sur la maladie de Parkinson
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Serveur d'exploration sur la maladie de Parkinson

CSF Aβ42 and tau in Parkinson's disease with cognitive impairment

CSF Aβ42 and tau in Parkinson's disease with cognitive impairment

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri